Generic Name: Chlorthalidone
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The information below is a summary of publicly available data, it should be considered outdated, unreliable, or straight up wrong. This website does not provide medical advice, everything on this website is for informational purposes only. Always consult a medical professional for accurate information about this drug.
Chlorthalidone is an oral antihypertensive/diuretic. It is a monosulfamyl diuretic that has a double-ring system incorporated in its structure. Its molecular formula is C14H11ClN2O4S and its molecular weight is 338.76. Chlorthalidone is practically insoluble in water and dichloromethane, but soluble in acetone and methanol. It is slightly soluble in 96% ethanol. Chlorthalidone tablets are available in two strengths: 25 mg and 50 mg. The tablets contain chlorthalidone as the active ingredient and other inactive ingredients including microcrystalline cellulose, pregelatinized starch (corn), sodium starch glycolate, colloidal silicon dioxide, stearic acid, and colorants D&C Yellow No.10 Aluminum Lake and FD&C Blue No.1 Aluminum Lake.
Diuretics like chlorthalidone are used to treat Hypertension alone or in combination with other antihypertensive drugs for more severe cases. It is also used as adjunctive therapy for edema associated with congestive heart failure, hepatic cirrhosis, and certain medication therapies. Chlorthalidone has shown effectiveness in treating edema caused by various forms of renal dysfunction. However, it is important to note that the routine use of diuretics in healthy pregnant women is not recommended. Diuretics do not prevent or treat toxemia of pregnancy. Edema during pregnancy can have pathological or physiological causes. Chlorthalidone is only indicated in pregnancy when edema is due to pathological causes. Treatment for dependent edema in pregnancy, caused by the pressure of the uterus on the veins, should focus on elevating the lower extremities and using support hose. The use of diuretics for this type of edema is unnecessary. It is common for pregnant women to experience harmless hypervolemia, which may lead to edema. Increased rest or, in extreme cases, a short course of diuretics may be appropriate for relieving discomfort.
