Generic Name: Lumacaftor and Ivacaftor
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Our coupons and discounts are generally accepted at most pharmacies; however, there may be instances where specific pharmacies cannot apply the coupon code or discount for Orkambi. Despite this, we encourage you to try using our coupons as they come with no cost to download, print, or display on your phone. You stand to gain potential savings!
This Orkambi coupon discount doesn't act as insurance. Sometimes the coupon offers even larger discounts than insurance. The coupon carries no risk - it's always worth asking the pharmacy about potential price reductions when using the coupon.
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The information below is a summary of publicly available data, it should be considered outdated, unreliable, or straight up wrong. This website does not provide medical advice, everything on this website is for informational purposes only. Always consult a medical professional for accurate information about this drug.
The active ingredients in ORKAMBI tablets are lumacaftor and ivacaftor. Lumacaftor has the chemical name 3-[6-({[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-3-methylpyridin-2-yl]benzoic acid, with the molecular formula C24H18F2N2O5 and molecular weight of 452.41. Ivacaftor is a CFTR potentiator with the chemical name N-(2,4-di-tert-butyl-5-hydroxyphenyl)-1,4-dihydro-4-oxoquinoline-3-carboxamide, with the molecular formula C24H28N2O3 and molecular weight of 392.49. Lumacaftor is a white to off-white powder that is practically insoluble in water. Ivacaftor is also a white to off-white powder that is practically insoluble in water. ORKAMBI tablets are available as pink, oval-shaped, film-coated tablets for oral administration. Each tablet contains 200 mg of lumacaftor and 125 mg of ivacaftor. The tablets also contain inactive ingredients such as cellulose, microcrystalline; croscarmellose sodium; hypromellose acetate succinate; magnesium stearate; povidone; and sodium lauryl sulfate. The tablet film coat contains carmine, FD&C Blue #1, FD&C Blue #2, polyethylene glycol, polyvinyl alcohol, talc, and titanium dioxide. The printing ink contains ammonium hydroxide, iron oxide black, propylene glycol, and shellac. ORKAMBI is also available as white to off-white granules for oral administration, contained in a unit-dose packet. Each packet contains lumacaftor and ivacaftor in different concentrations. The granules also contain inactive ingredients such as cellulose, microcrystalline; croscarmellose sodium; hypromellose acetate succinate; povidone; and sodium lauryl sulfate.
ORKAMBI is a medication used to treat Cystic Fibrosis (CF) in patients aged 1 year and older who have the F508del mutation in the CFTR gene. It is a combination of ivacaftor and lumacaftor. It is important to use an FDA-cleared CF mutation test to confirm the presence of the F508del mutation before using ORKAMBI. The effectiveness and safety of ORKAMBI have not been studied in patients with CF who do not have the F508del mutation.
